Peptide Therapy in Rancho Santa Margarita, CA

85 med spas offer peptide therapy in and around Rancho Santa Margarita, compared by Google rating and who does the treatment. New to it? Read our peptide therapy guide.

85Med spas
4.9Top rating
Photo: Don Ramey Logan, CC BY-SA 3.0

85 Peptide Therapy Providers Near Rancho Santa Margarita

Spas in Rancho Santa Margarita first, then nearby, each ranked by Google rating weighted by number of reviews. No spa paid to be on this page. How we rank

1
R
Rancho Santa Margarita · 30451 Avenida de las Flores Ste b · 0.2 mi

Rejuve Anti Aging

4.9 (291 Google reviews)
CoolSculptingDiamondGlow

Rejuve Anti Aging is a medical spa and wellness clinic in Rancho Santa Margarita, CA, offering personalized treatments in regenerative medicine, stem cell therapy, aesthetics, hormone optimization, medical weight loss, and anti-aging…

Online bookingMembership
2
Newport Beach Location⊞ 5 photos
Rancho Santa Margarita · 22032 El Paseo #100 · 0.4 mi

Pure Beauty Medical Spa

4.5 (51 Google reviews)
Laser GenesisVivace

At Pure Beauty Skin Care and Medical Spa, you can enhance your natural beauty with cosmetic treatments that are the latest in medical technology. California's Premier Medical Spa and Top 5 Provider of Botox and Filler in the US Since…

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3
IMG_1265.JPG⊞ 4 photos
Corona · 2279 Eagle Glen Pkwy STE 110 · 13.4 mi

Derma Aesthetica Med Spa

5.0 (443 Google reviews)
Clear + BrilliantSciton BBL

Step into Derma Aesthetica Med Spa, Corona's premier destination for advanced aesthetic treatments. Derma Aesthetica is rated the #1 Med Spa in Corona, CA. Since our opening on April 1st, 2024, our expert team has been dedicated to…

Women-ownedMembership
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4
D
Tustin · 2530 Bryan Ave B · 12.9 mi

Dream Med Spa

5.0 (378 Google reviews)
Laser GenesisUltherapy

Dream Med Spa is Orange County's premier destination for advanced, non-surgical aesthetic treatments. Since opening its doors in 2021, the Tustin-based med spa has specialized in providing men and women with cutting-edge solutions for…

Membership
View ProfileWebsite✓ Takes requests

Most Rancho Santa Margarita spas don't post prices.

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Get Quotes From 3 Spas
5
Hydraf.jpg⊞ 4 photos
San Juan Capistrano · 27372 Calle Arroyo Ste C · 10.0 mi

SM Drip Med Spa

5.0 (255 Google reviews)

SM Drip is a physician-owned and -operated premier med spa in San Juan Capistrano, CA, offering a range of services designed to rejuvenate and enhance your natural beauty. Our top services include IV therapy for hydration and wellness…

Online bookingMembershipLGBTQ+ friendly
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6
NuBella Med Spa⊞ 4 photos
Irvine · 62 Corporate Park #100 · 13.4 mi

NuBella Med Spa

5.0 (219 Google reviews)
DiamondGlowInMode

Luxury Medical Spa with locations in Orange County + Rancho Cucamonga Since 2018, our mission at NuBella Med Spa is to support and enhance the natural beauty of our patients by providing a customized experience that empowers you from…

Women-ownedOnline bookingMembership
7
M
Irvine · 39 Creek Rd #280 · 11.5 mi

Masters Medspa

5.0 (170 Google reviews)
Sofwave

At Masters Medspa™ in Irvine, California, we combine luxury, science, and artistry to help you look and feel your best. Founded by Nurse Practitioner Allison Brewer, NP, and Dr. Chantell Lunderville, MD, our medical spa specializes in…

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9
cosmetic treatments
Lake Forest · 23321 El Toro Rd Ste G · 5.6 mi

AquaVita Wellness & Medspa

5.0 (118 Google reviews)
InModeMorpheus8

At AquaVita Wellness & Med Spa in Lake Forest, Orange County, CA, we offer personalized treatments designed to enhance your natural beauty and well-being. Our expert team provides a range of services to rejuvenate your skin, sculpt your…

Women-ownedOnline booking
View ProfileWebsite✓ Takes requests
10
OHMI ANTI-AGING CENTER - Regenerative Aesthetics - Medspa
Irvine · 3500 Barranca Pkwy Ste 290 · 12.7 mi

OHMI ANTI-AGING CENTER - Regenerative Aesthetics - Medspa

5.0 (112 Google reviews)
LumenisUltherapy

Welcome to OHMI Anti-Aging Center in Irvine, California, an award-winning anti-aging medical practice and nationally recognized leader in regenerative aesthetics founded on the philosophy that the safest, longest-lasting, and highest…

Online bookingLGBTQ+ friendly
View ProfileWebsite✓ Takes requests

More Peptide Therapy Providers Near Rancho Santa Margarita

Sorted by rating × reviews · distance from central Rancho Santa Margarita
#Med spaRatingDistancePrice posted
11CQ Med Gym 5.0 (105)11.1 mi—
12Dolce MD 5.0 (104)12.4 mi—
13Renu Facial And Body Aesthetics 5.0 (101)9.8 mi—
14Lux Medical OC 5.0 (100)9.4 mi—
15Biolite Wellness 5.0 (94)9.3 mi—
16Orange Sculpting & Aesthetics Center 5.0 (93)7.8 mi—
17Age Well Acupuncture & Med Spa 5.0 (78)6.5 mi—
18Gravity Medical Spa 4.9 (600)10.0 mi—
19Restore Hyper Wellness 4.9 (364)11.7 mi—
20Ageless MD 4.9 (319)14.5 mi—
21ULS AllCare 4.9 (312)13.4 mi—
22The Cove Integrative Aesthetics & Wellness 5.0 (56)12.8 mi—
23Skin Canvas Aesthetics 5.0 (55)9.4 mi—
24Dr. Chi-Whei Lin, MD, Inc. 5.0 (52)6.7 mi—
25OC Weight Loss & Med Spa 4.9 (196)5.0 mi—
26Spectrum Skin Clinic 5.0 (45)9.0 mi—
27Le Renew 5.0 (44)6.6 mi—
28Suncare Medspa-尔湾最好的医美中心 Botox 注射美容 溶脂注射 水光针 皮秒激光 热玛吉 超声刀提升 光子嫩肤 玻尿酸填充 抗衰老 洛杉矶FDA认证医疗美容 Irvine CA 橙县顶级医学美容诊所 推荐 4.9 (138)9.5 mi—
29Aesthetic Haus Med Spa 5.0 (43)7.3 mi—
30Belle Moi MedSpa 5.0 (42)8.0 mi—
31Slender Me Medical 4.9 (124)14.9 mi—
32Mission Med Spa 4.9 (99)10.5 mi—
33Regenerative Aesthetics and Dermatology 4.9 (82)5.4 mi—
34AgeRefine Clinic 5.0 (31)11.1 mi—
35Med Lounge 4.9 (65)5.5 mi—
36Total Skin and Wellness - Weight Loss Peptides, BPC-157, Retatrutide, Tirzepatide, GLOW, Semaglutide, Intimate Whitening 4.9 (65)12.8 mi—
37Timothy R. Miller, MD: Refreshed Aesthetic Surgery 4.9 (59)8.8 mi—
38Med Aesthetics OC 4.9 (57)14.3 mi—
39NuAge Spa 4.9 (54)5.5 mi—
40Not Just Faces Medical Aesthetics 5.0 (26)10.3 mi—
Showing 11–40 of 85
From Google reviews

What Rancho Santa Margarita Patients Mention Most

Topics Google pulls from the reviews of the top 10 spas above, counted by mentions.

Iv drip57SM Drip Med Spa
Weight loss41Derma Aesthetica Med Spa
Injector33Masters Medspa
Professional team30Derma Aesthetica Med Spa
Fillers30EverGlow Aesthetics
Knowledgeable doctor27OHMI ANTI-AGING CENTER - Regenerative Aesthetics - Medspa
Nurse b24NuBella Med Spa
Friendly team23SM Drip Med Spa
Dr jen natural22OHMI ANTI-AGING CENTER - Regenerative Aesthetics - Medspa
Ipl treatment17Dream Med Spa
Credentials

Who Does It in Rancho Santa Margarita

Roles named on the websites of the top 10 spas (6 of them list their team).

Physician (MD or DO)3 of 6
Nurse practitioner (NP)3 of 6
Physician assistant (PA)1 of 6
Registered nurse (RN)4 of 6
Licensed esthetician1 of 6
Devices

Devices Rancho Santa Margarita Spas Name

Named by 43 of the 60 spas we checked.

DeviceSpas
Ultherapy13
Morpheus813
CoolSculpting12
Sciton BBL12
Emsculpt10
Emsculpt NEO10
DiamondGlow8
PicoSure7

Peptide Therapy Near Rancho Santa Margarita by the Numbers

85spas list peptide therapy within 15 miles
24%of the 359 med spas within 15 miles
4.88average Google rating of those spas (83 rated)

85 of the 359 med spas within about 15 miles of Rancho Santa Margarita list peptide therapy on their Google profile or website.

Those 83 rated providers average 4.88 on Google, and 73 hold a 4.8 or higher.

How We Built This Page

Every number here comes from a spa's Google profile or its own website. Nothing is paid for.
Ranked by reviews, not ads. Google rating weighted by how many people left one.
Prices from each spa's own site. Copied from their websites, checked October 2026.
Devices and credentials only when named. If a spa doesn't say, we leave it blank.
Not phone-verified yet. Prices and staff change, so confirm when you book.
Frequently asked questions

Peptide Therapy in Rancho Santa Margarita: Common Questions

What is the best-rated peptide therapy provider in Rancho Santa Margarita?

Rejuve Anti Aging ranks first on our list, with a 4.9 rating from 291 Google reviews.

We rank by star rating weighted by how many people left one, so a 5.0 from hundreds of patients beats a 5.0 from a handful.

How many med spas offer peptide therapy near Rancho Santa Margarita?

We list 85 within about 15 miles of Rancho Santa Margarita, based on each spa's Google profile and website.

Are peptide therapy providers near Rancho Santa Margarita well rated?

The 83 rated spas within 15 miles that list peptide therapy average 4.88 out of 5 on Google, and 73 hold a 4.8 or higher.

We rank them by rating weighted by how many reviews each has.

What are the med spa rules in California?

Our California page sums up what state law and the licensing boards say about who may do med spa treatments, with a source for each rule.

Med spa rules in California

Which devices do Rancho Santa Margarita med spas use?

43 of the 60 spas we checked name a device on their website.

The most common are Ultherapy (13), Morpheus8 (13), CoolSculpting (12).

Ask any spa that doesn't say which device it uses.