Key takeaways
- Jeuveau's only FDA-approved use is glabellar lines (frown lines) in adults.
- Its units cannot be compared to or converted into Botox units, and no official conversion exists.
- The label states no onset or duration; the two-day and four-month figures come from the manufacturer.
- We found no primary source on Jeuveau consumer prices, so ask each practice for its per-unit price and planned units in writing.
- Like all botulinum toxin products, Jeuveau carries an FDA boxed warning about distant spread of toxin effect.
What is Jeuveau (prabotulinumtoxinA-xvfs)?
Jeuveau is the brand name for prabotulinumtoxinA-xvfs, a prescription injection of botulinum toxin type A.
It is marketed by Evolus and manufactured at Daewoong Pharmaceutical in Korea; the label describes a vial containing 100 units of the toxin complex, with human serum albumin among its ingredients.
Jeuveau received FDA approval on February 1, 2019, for glabellar lines — the frown lines between the eyebrows — in adults, and it is approved only for that aesthetic indication.
The labeled treatment is a 20-unit dose, given as 4 units into each of five sites, with retreatment no more often than every three months.
It belongs to the same category as the other injectable wrinkle relaxers.
The American Society of Plastic Surgeons' 2025 procedural statistics report says neuromodulator injections — it names Botox, Dysport, Letybo, Xeomin, Jeuveau and Daxxify — accounted for about half of all minimally invasive procedures performed in 2025, with hyaluronic acid fillers another 30% of the total.
Our neurotoxin brands comparison covers the whole category, brand by brand.
What makes Jeuveau different from Botox?
Both are botulinum toxin type A injections, but they are different products. Botox Cosmetic's active ingredient is onabotulinumtoxinA, from Allergan/AbbVie; Jeuveau's is prabotulinumtoxinA-xvfs, from Evolus, made at Daewoong in Korea.
Their approval scopes differ most: Botox Cosmetic's label covers four cosmetic areas — frown lines, crow's feet, forehead lines and vertical neck bands — while Jeuveau's covers frown lines only.
Jeuveau vs Botox Cosmetic
| Jeuveau | Botox Cosmetic | |
|---|---|---|
| Active ingredient | prabotulinumtoxinA-xvfs | onabotulinumtoxinA |
| Maker | Evolus (made at Daewoong, Korea) | Allergan/AbbVie |
| Approved cosmetic areas | Frown lines only | Frown lines, crow's feet, forehead lines, vertical neck bands |
| Units convertible to the other? | No | No |
Units are not interchangeable.
Every US botulinum toxin label, including both of these, states that its units cannot be compared to or converted into units of another product, and no official conversion between the brands exists.
A 20-unit dose of one is not a label-endorsed match for a 20-unit dose of the other.
The one head-to-head trial our research found is a 2025 randomized trial in JAMA Dermatology that compared Botox 20 units, Dysport 60 units, Jeuveau 20 units and Xeomin 20 units on the frown lines of 143 women at a single center.
Dysport and Jeuveau showed the fastest onset at day 3, and Jeuveau and Xeomin retained efficacy at day 180 compared with baseline.
It is one trial, measured with a 3D "dynamic strain" imaging outcome rather than wrinkle severity scales — a data point, not a settled ranking.
On price, we found no usable comparison: our research found no primary source on Jeuveau list or average consumer prices, and Evolus's own site advertises membership offers rather than prices.
A "cheaper than Botox" claim is not something we could verify.
If a price list converts Jeuveau units into Botox units, that math has no basis on the labels: each states its units cannot be compared to or converted into the other's, and no official conversion between the brands exists.
What areas does Jeuveau treat?
On Jeuveau's label, exactly one area appears: the glabellar lines.
Its boxed warning states that the product is not approved for the treatment of spasticity or any conditions other than glabellar lines, which makes frown lines the product's entire approved scope.
Forehead lines and crow's feet are not on Jeuveau's label.
Treating those areas with it is off-label: the use is not on any current US label for the product.
The same applies to uses like jaw slimming or a lip flip — no US neurotoxin label includes the lips, and none of those areas is on Jeuveau's.
Product and area do not always match on a clinic menu, because labels differ in scope.
Botox Cosmetic is approved for frown lines, crow's feet, forehead lines and vertical neck bands.
If you are quoted a toxin treatment for an area, it is a fair question to ask which product is being used and whether that area is on its label.
Off-label means the use is not on the product's FDA label. For Jeuveau, frown lines are the only labeled area, so any other area — forehead, crow's feet, jaw, lips — is an off-label use of this product.
Find Jeuveau providers near you
Compare Google ratings, reviews and posted prices at med spas in your city.
What does Jeuveau cost per unit?
Botulinum toxins are typically priced per unit or per treatment area, so the price of an area works out to roughly the number of units times the practice's per-unit price.
Jeuveau's label gives a starting point for the count: the labeled frown-line dose is 20 units, and the product is supplied in vials the label describes as containing 100 units.
Beyond that structure, this page cannot give you a number.
No current national average fee for neuromodulators is available to us — the ASPS 2025 statistics report omits minimally invasive fees — and we found no primary source on Jeuveau list or average consumer prices; Evolus publishes membership and reward offers rather than prices.
Per-unit pricing is a question to put to each practice you are considering, in writing, before you book.
Evolus's own programs, as its site described them when we read it in October 2026: a Club Evolus membership covers 20 units of Jeuveau per treatment, with at least 90 days between treatments; units do not accrue if you wait more than 90 days; members are opted out of Evolus Rewards; and the site advertises $40 off every 90 days through Evolus Rewards.
The page we saved did not show a membership price, and program terms change, so treat these as the manufacturer's current offer rather than a market price.
Ask each practice for its price per unit and how many units it plans to inject — the labeled frown-line dose is 20 units — and get both in a written quote.
How fast does Jeuveau work, and how long does it last?
Start with what the label does not say: Jeuveau's label gives no onset or duration statement in days or months.
It reports efficacy at a day-30 primary endpoint, so the label itself is silent on both how fast it appears and how long it lasts.
The two-day and four-month figures you will see come from the manufacturer.
Evolus says results can start in as little as two days and can last for up to four months, citing a phase III trial published by Rzany and colleagues in Aesthetic Surgery Journal in 2020 in which about half of the patients showed improvement after two days.
Those are the manufacturer's figures, not label statements.
For botulinum toxin as a class, the American Academy of Dermatology's consumer guidance says most people see results within 3 to 7 days, with improvements that last about three to four months, sometimes longer.
And in the 2025 JAMA Dermatology trial above, Jeuveau was among the fastest to show onset at day 3 and still showed efficacy at day 180 versus baseline.
Where the onset and duration figures come from
| Source | Onset | Duration |
|---|---|---|
| Jeuveau label | No statement (efficacy measured at day 30) | No statement |
| Evolus (manufacturer) | As little as two days | Up to four months |
| AAD (toxins as a class) | Within 3 to 7 days | About three to four months, sometimes longer |
| 2025 JAMA Dermatology trial | Day 3 (among the fastest) | Efficacy at day 180 vs baseline |
Whatever figure you use, the label sets one boundary: retreatment should be no more often than every three months.
Unlike Botox Cosmetic, whose label gives about three to four months for frown lines, Jeuveau's label states no duration at all. The two-day and four-month figures you will see are the manufacturer's.
What are Jeuveau's side effects?
In Jeuveau's clinical trials, the label lists the most common adverse reactions as headache (12%), upper respiratory tract infection (3%), eyelid ptosis — a drooping of the upper eyelid (2%) — and increased white blood cell count (1%).
These are the rates reported in the product's trials, as summarized on the label; they describe groups, not a prediction for any one person.
Most common adverse reactions in Jeuveau's trials
Share of trial patients, as listed on the label
Source: Jeuveau prescribing information
Your provider can review the label's full warnings with you before treatment, including what to watch for afterwards.
Jeuveau carries the FDA boxed warning that applies to all botulinum toxin products: effects may spread from the injection area and cause symptoms such as generalized weakness, double vision, drooping eyelids, and swallowing or breathing difficulty, reported hours to weeks after injection. Swallowing and breathing problems can be life threatening and there have been reports of death. Contact your provider about these symptoms, and seek emergency care for trouble swallowing or breathing.
Jeuveau reviews: what patients say
MedSpaStandard does not republish review-site ratings or patient anecdotes, so this page has no star rating to hand you.
For Jeuveau specifically, the research for this guide found no independent patient-satisfaction survey we could verify.
What the record does contain is clinical: a phase III trial figure the manufacturer cites — about half of the patients showed improvement after two days, as Evolus tells it — and the 2025 JAMA Dermatology trial in which Jeuveau was among the fastest to act and still showed efficacy at day 180.
Two caveats apply to reviews and trial figures alike.
Group averages are not a prediction for any one person, and a review may not state which product was injected, at what dose or in which area — details that change what a result means.
If reviews inform your shortlist, favor ones that name the injector, the product and the units.
Finding Jeuveau near you
Who may inject Jeuveau is a matter of state law.
AmSpa's published position is that injecting a botulinum toxin is the practice of medicine — it is a prescription drug acting on living tissue — so it must be done by a physician, an independent-practice NP or another licensed professional acting within their scope, under rules that vary by state.
Our guide to med spa laws explains how supervision rules differ, and how to choose a med spa covers credentials and red flags in depth.
Counterfeit product is why the source question is not theoretical: on April 16, 2024, FDA warned that unsafe counterfeit Botox had been found in multiple states and given to consumers for cosmetic purposes, with adverse events including hospitalizations.
FDA said the incidents involved products apparently bought from unlicensed sources, and federal law requires providers to buy prescription drugs only from authorized sources.
The CDC's consumer advice follows from that: get botulinum toxin injections only from a licensed, trained provider using product from an authorized source, and treat the procedure as not free of risk even when FDA-approved product is given correctly.
- Who will inject: a physician, an independent-practice NP or another licensed professional acting within their scope, per AmSpa's description of the rules — which vary by state.
- Where the product comes from: the CDC advises botulinum toxin injections only from a licensed, trained provider using product from an authorized source.
- What the label covers: Jeuveau's label covers frown lines only, so for any other area ask which product is being used and whether that area is on its label.
- The numbers in writing: the price per unit and the planned units — the labeled frown-line dose is 20 units.
None of this is a recommendation for or against treatment for any one reader — that conversation belongs with a licensed provider who can examine your frown lines, review the label with you and quote the actual numbers.
Frequently asked questions
Is Jeuveau the same as Botox?
No. Jeuveau's active ingredient is prabotulinumtoxinA-xvfs, marketed by Evolus and made at Daewoong in Korea; Botox Cosmetic's is onabotulinumtoxinA, from Allergan/AbbVie.
Their labels differ too: Jeuveau's only approved use is frown lines, while Botox Cosmetic covers frown lines, crow's feet, forehead lines and neck bands.
Units cannot be converted between them, and no official conversion exists.
Both are botulinum toxin type A products, so both labels carry the same boxed warning about distant spread of toxin effect.
How much does Jeuveau cost?
We could not confirm a national average.
The ASPS 2025 statistics report omits fees for minimally invasive procedures, and we found no primary source for Jeuveau list or average consumer prices.
Toxins are typically priced per unit or per treatment area, and Jeuveau's labeled frown-line dose is 20 units.
Evolus's Club Evolus membership covers 20 units per treatment, per Evolus's site.
Ask each provider for its per-unit price and how many units it plans.
How long does Jeuveau last?
The Jeuveau label states no duration; it reports efficacy at a day-30 primary endpoint.
Evolus says results can last up to four months, a manufacturer figure.
For botulinum toxin generally, the American Academy of Dermatology gives about three to four months, sometimes longer, and a 2025 trial of 143 women found Jeuveau still effective at day 180 versus baseline.
The label says retreatment should be no more often than every three months.
Is Jeuveau approved for forehead lines or crow's feet?
No. FDA approval, dated February 1, 2019, covers glabellar lines in adults, and the label's boxed warning states Jeuveau is not approved for any condition other than glabellar lines.
Treating forehead lines or crow's feet with Jeuveau is off-label: the use is not on any current US label for the product.
Botox Cosmetic does carry approvals for those areas, so it is a fair question to ask which toxin a quoted treatment uses.
Sources
Every number on this page comes from one of these sources and was checked against it.
- BOTOX COSMETIC- onabotulinumtoxina injection, powder, lyophilized, for solution · DailyMed, U.S. National Library of Medicine
- Drugs@FDA: FDA-Approved Drugs · U.S. Food and Drug Administration
- JEUVEAU- prabotulinum toxin type a powder · DailyMed, U.S. National Library of Medicine
- Comparison of Botulinum Toxin A Formulations for Glabellar Strain Treatment in Women: A Double-Blind Randomized Clinical Trial · Lemdani et al., JAMA Dermatol, 2025
- Counterfeit Version of Botox Found in Multiple States · U.S. Food and Drug Administration
- cdc.gov · CDC
- plasticsurgery.org · American Society of Plastic Surgeons
- Jeuveau · jeuveau.com
- Botulinum toxin therapy: Overview · American Academy of Dermatology
- What Are the Rules for Who Can Inject Neurotoxins? · American Med Spa Association
Medical disclaimer. MedSpaStandard is for education only and is not medical advice. Talk to a licensed provider about your own health, and check any provider's license with your state board.