Key takeaways
- Each Juvederm product has its own FDA-approved areas; one product's approval never transfers to another.
- Only Ultra XC and Volbella XC are approved for the lips.
- Juvederm's ISI says most common side effects resolve within 30 days.
- FDA warns that Juvederm Ultra 2, 3 and 4 are not approved in the US and should not be used.
What is Juvederm?
Juvederm is Allergan's collection of hyaluronic acid (HA) dermal fillers.
Allergan describes the collection as six FDA-approved HA fillers — Voluma XC, Volux XC, Vollure XC, Volbella XC, Ultra Plus XC and Ultra XC — covering cheeks, chin, temples, smile lines, lips, under-eyes and jawline, and says the line treats 10 areas of the face in all.
Allergan also says all six fillers contain pain-reducing lidocaine.
Hyaluronic acid is a sugar (polysaccharide) that the FDA describes as naturally present in skin and cartilage; the HA in fillers is made from bacteria or rooster combs and is often chemically crosslinked so that it holds up longer.
Legally, these are regulated as medical device implants rather than as drugs: FDA approves dermal fillers through premarket approval (PMA) and describes them as implants approved to create a smoother and/or fuller appearance in the face — including the nasolabial folds (smile lines), cheeks, chin, lips and back of the hands.
The dated Juvederm approvals in this guide — Voluma XC, Volux XC, Vollure XC, Volbella XC, Ultra XC for the lips, and SKINVIVE — are each for adults over 21.
FDA's general statement is that fillers are approved for adults aged 22 or older — meaning over 21 — with each product's label setting the exact age.
All six Juvederm products are hyaluronic acid.
FDA groups HA with calcium hydroxylapatite and poly-L-lactic acid (the material in Sculptra) as the absorbable, temporary filler materials; the dermal fillers guide covers the other brands and materials.
SKINVIVE by Juvederm is related but counted separately: FDA approved it in 2023 to improve cheek skin smoothness and expanded it to neck lines in 2026, while Allergan counts six fillers in the Juvederm collection and does not list SKINVIVE among them.
Juvederm products and what each treats
Each Juvederm product carries its own approved indications, and one product's approval never transfers to another.
Every approval below is a premarket approval (PMA) — the path FDA uses for fillers, which it regulates as medical device implants — with the dates taken from FDA's PMA records.
| Product | Approved indication | Approved |
|---|---|---|
| Juvederm Voluma XC | Cheek augmentation to correct age-related volume deficit in the midface | 2013 |
| Juvederm Voluma XC | Chin augmentation, to improve the chin profile | 2020 |
| Juvederm Voluma XC | Temple augmentation for moderate to severe temple hollowing | 2023 |
| Juvederm Volux XC | Improvement of jawline definition in adults with moderate to severe loss of jawline definition | 2022 |
| Juvederm Vollure XC | Moderate to severe facial wrinkles and folds, such as nasolabial folds (no lip indication) | 2017 |
| Juvederm Volbella XC | Lip augmentation and correction of perioral lines | 2016 |
| Juvederm Volbella XC | Improvement of under-eye (infraorbital) hollowing — the first US filler approved there | 2021 |
| Juvederm Ultra Plus XC | Moderate to severe facial wrinkles and folds, such as nasolabial folds (no lip indication) | — |
| Juvederm Ultra XC | Lip augmentation in the lips and perioral area, plus moderate to severe facial wrinkles and folds such as nasolabial folds | 2015 |
| SKINVIVE by Juvederm | Cheek skin smoothness; neck lines (added 2026) | 2023 |
Notice how narrow each approval is.
Ultra XC is approved for the lips; Ultra Plus XC is not. Voluma XC's approvals cover cheeks, chin and temples — not lips.
Any use outside the product's own label, such as Volbella XC in the jawline or any Juvederm filler in the nose, is off-label: it is not on any current US label for that product.
The off-label territory does not end at the examples above: FDA's PMA approval orders on file as of October 2026 show no US filler with an approved indication for the nose, the glabella, the forehead, the buttocks/hips or the breasts.
For lips specifically, the two approved Juvederm options are Ultra XC (2015) and Volbella XC (2016); the lip filler guide covers the approved lip fillers, cost and results.
How much does Juvederm cost?
There is no single Juvederm price.
Allergan's consumer site says Juvederm treatment can range from "$600–$1,400", with the total varying by the products chosen and by provider — a manufacturer figure, read on Allergan's site in October 2026, that Allergan does not break down per syringe or per treatment.
ASPS, the plastic surgery professional society, lists average costs of $715 for hyaluronic acid fillers and $743 for lip augmentation with filler.
Those are average fees reported by ASPS member plastic surgeons — not med spa prices — and the ASPS page does not state the data year.
What moves the price: ASPS names the injector's expertise and qualifications, the type of procedure, the time and effort involved, and the geographic location of the office.
ASPS also notes that health insurance does not cover dermal fillers.
Maker programs can discount the sticker price: Allergan's Allē loyalty program gives 100 points = $10 toward qualifying treatments, including Juvederm.
None of the national figures above sets the price at any particular practice.
Ask any provider you are considering for a written quote that names the exact product and the amount before you book.
Allergan's 2026 Juvederm Day — the fourth annual, held August 19, 2026 — gave Allē members a buy-one-get-one $75 Juvederm gift card at JuvedermDay.com while supplies lasted, plus double Allē points on up to two syringes of Juvederm from August 19 to 31, 2026. The 2026 event has ended; any future terms are Allergan's to set.
How long does Juvederm last?
It depends on the product and the area, because each carries its own data.
FDA's material-level estimate is that the effects of hyaluronic acid fillers "last approximately 6 – 12 months", and FDA groups HA among the absorbable (temporary) filler materials — no Juvederm product is a permanent filler.
Allergan states its own maximums for each product and area "with optimal treatment," and several of them run past FDA's material-level estimate.
Allergan's stated maximums:
| Product — area | Allergan's stated maximum |
|---|---|
| Voluma XC — cheeks | Up to 2 years |
| Voluma XC — temples | Up to 13 months |
| Voluma XC — chin | Up to 1 year |
| Vollure XC — smile lines | Up to 18 months |
| Ultra Plus XC — smile lines | Up to 1 year |
| Volux XC — jawline | Up to 1 year |
| Volbella XC — under-eyes | Up to 1 year |
| Volbella XC and Ultra XC — lips | Up to 1 year |
Read those for what they are: manufacturer "up to" claims on the maker's own website — stated maxima rather than averages, and not a promise of any individual result.
Allergan says Juvederm results are visible immediately after treatment, and that the products are injected with a needle or a cannula.
Its safety information also lists swelling among the most common side effects, most of which resolve within 30 days — so the first days are not the finished picture.
Side effects
Juvederm's own Important Safety Information (ISI) names the most common side effects: redness, swelling, pain, tenderness, firmness, lumps/bumps, bruising, discoloration and itching — plus dryness with Volbella XC — and says most resolve within 30 days.
The ISI adds that persistent side effects may be treated with antibiotics, steroids or hyaluronidase.
FDA's filler-wide list is broader.
Common risks: bruising, redness, swelling, pain, tenderness, itching and rash.
Less common: nodules or granulomas, infection, allergic reaction and necrosis.
Rare reported risks: anaphylaxis, migration of filler, permanent hard nodules, blindness, stroke and death.
Two findings from Allergan's own studies show the span the company reported: in the Voluma XC cheek study the most common side effects were moderate and generally lasted 2 to 4 weeks; in the Volbella XC lip study they were mild or moderate and generally resolved within 30 days.
Delayed-onset nodules are documented with Allergan's Vycross-technology fillers (Volbella, Vollure, Voluma): a Canadian clinic series of 2,139 patients counted them in 0.33% of patients, and an earlier US chart review put Volbella XC at 1.0% per patient, with none seen for Vollure or Voluma; every nodule in the US series resolved with steroid injection plus hyaluronidase.
These are single-clinic figures, not product-wide rates.
Labeling also sets exclusions.
Juvederm's ISI says the products should not be used by anyone with a history of multiple severe allergies or anaphylaxis, an allergy to lidocaine or to the gram-positive bacterial proteins used in the products, or prior allergic reactions to hyaluronic acid fillers.
FDA adds that filler safety is unknown during pregnancy and breastfeeding, and that treatment should be delayed if the skin in the area is inflamed or infected.
Aftercare, per Juvederm's labeling: avoid makeup for 12 hours after treatment, and minimize strenuous exercise, extensive sun or heat exposure and alcohol for the first 24 hours, because these may cause temporary redness, swelling and/or itching.
Aftercare, per Juvederm's labeling
| Step | Time window |
|---|---|
| Avoid makeup | 12 hours after treatment |
| Minimize strenuous exercise | First 24 hours |
| Minimize extensive sun or heat | First 24 hours |
| Minimize alcohol | First 24 hours |
Reversal is not an undo button.
Allergan's ISI states that the effectiveness of removal of any dermal filler has not been studied, and FDA-approved hyaluronidase products such as Hylenex are approved only to aid subcutaneous fluid administration, increase the dispersion and absorption of other injected drugs, and in subcutaneous urography — so using hyaluronidase to dissolve filler is off-label.
FDA calls unintentional injection into a blood vessel the most concerning filler risk. Rare, but it can cause tissue death (necrosis), vision problems including blindness, and stroke, and the damage may be permanent. FDA says to seek immediate medical attention for unusual pain, vision changes, white, gray or blue skin near the injection site, or any signs of stroke.
Juvederm vs Restylane
The brand-to-brand comparison for Juvederm is Restylane, Galderma's hyaluronic acid filler family.
Both lines work the same legal way — each product carries its own FDA-approved indications — so the comparison that matters is product by product, not brand versus brand.
Three concrete differences from the approval record:
- Lips came first for Restylane: Restylane was approved for lip augmentation in 2011 (Restylane-L followed in 2012), the first US filler with a lip indication, while Juvederm's first lip approval was Ultra XC in 2015, followed by Volbella XC in 2016.
- Under the eyes came first for Juvederm: Volbella XC was approved for infraorbital hollowing in 2021, the first US filler approved there; Restylane Eyelight followed in 2023.
- The hands: only two US fillers are approved for hand rejuvenation — Radiesse (2015) and Restylane Lyft (2018). No Juvederm product is among them.
Longevity is where comparisons go wrong, because the two makers publish different kinds of figures.
Allergan says Volbella XC and Ultra XC can hold results in the lips for up to 1 year with optimal treatment — a manufacturer claim.
Restylane Kysse's own pivotal trial measured that 60% of 169 treated subjects were still lip-fullness responders at week 48 — a trial result.
Different products, different measures; neither figure predicts the other product's outcome, and neither predicts yours.
The rewards programs differ too.
Allergan's Allē gives 100 points = $10 toward qualifying treatments including Juvederm.
Galderma's ASPIRE program — for Restylane, Sculptra and other Galderma products — offers a $20-off welcome reward, 100 points = $10 in savings and up to 600 points per visit, per Galderma's Restylane site.
Program terms change, so check both before you book.
Allē (Allergan)
- 100 points = $10 toward qualifying treatments
- Qualifying treatments include Juvederm
ASPIRE (Galderma)
- $20-off welcome reward
- 100 points = $10 in savings
- Up to 600 points per visit
- Covers Restylane, Sculptra and other Galderma products
Find a Juvederm provider near you
FDA advises choosing a licensed health care provider with dermatology or plastic-surgery experience who is trained in filler injection, and says filler injection should be considered a medical procedure, not a cosmetic treatment.
Product authenticity is part of the check.
FDA warns that unapproved versions of Juvederm — Juvederm Ultra 2, 3 and 4 — have been sold in the US, including online, and should not be used.
The agency also says no filler is approved for over-the-counter use and advises people not to inject themselves or buy filler online.
Training can even be product-specific: Allergan's ISI for Volbella XC says the under-eye treatment should be injected only by doctors who have completed Allergan's training.
For credentials, red flags and payment options across the whole med spa menu, the Med spa guide walks through the vetting checklist.
- Which Juvederm product will you use, and what is it FDA-approved for in the area I want treated?
- If the plan is an off-label use, what does that mean in my case?
- What training have you had with this product and in this area?
- Can you show me the sealed product and its label before treatment?
- What will the total cost be, including any touch-up?
Frequently asked questions
Is Juvederm safe?
No guide can promise that; here is what the record shows.
FDA lists bruising, swelling, redness, pain, tenderness, itching and rash among common filler risks, and Juvederm's ISI says most common side effects resolve within 30 days.
Rare but serious risks include unintentional injection into a blood vessel, which FDA calls the most concerning filler risk.
Juvederm's ISI says the products are not for people with a history of multiple severe allergies or anaphylaxis, lidocaine allergy, allergy to the gram-positive bacterial proteins used, or prior reactions to HA fillers.
A licensed provider can weigh your own history.
How old do you have to be to get Juvederm?
The dated Juvederm approvals in this guide — Voluma XC, Volux XC, Vollure XC, Volbella XC, Ultra XC for the lips, and SKINVIVE — are each for adults over 21.
FDA states that dermal fillers are approved for adults aged 22 or older — meaning over 21 — and that each product's label sets the exact age.
FDA also notes that filler safety is unknown under age 22, as it is during pregnancy and breastfeeding.
Anyone below a product's labeled age sits outside that product's approval.
Can Juvederm be dissolved if you don't like the result?
Juvederm is a hyaluronic acid filler, and hyaluronidase breaks hyaluronic acid down — Cleveland Clinic notes it dissolves only HA fillers, and that lip filler can usually be dissolved in one to two visits.
But dissolving is off-label: FDA-approved hyaluronidase products such as Hylenex are approved only for other uses, and Allergan's ISI says the effectiveness of removal of any dermal filler has not been studied.
Ask a licensed provider what removal would involve in your case.
How long does Juvederm hold in the lips?
Allergan gives up to 1 year with optimal treatment for Juvederm Volbella XC and Ultra XC in the lips — the maker's stated maximum, not an average and not a promise.
As a different kind of measure, in Restylane Kysse's pivotal trial 60% of 169 treated subjects were still lip-fullness responders at week 48.
The product chosen, the area and the person all matter, so discuss your case with a licensed provider.
What is Juvederm Day?
An annual Allergan promotion for its Allē loyalty members, held in August.
The 2026 event — the fourth annual, on August 19 — offered Allē members a buy-one-get-one $75 Juvederm gift card at JuvedermDay.com while supplies lasted, plus double Allē points on up to two syringes of Juvederm from August 19 to 31, 2026.
The 2026 event has ended; future events and their terms are Allergan's to announce.
Sources
Every number on this page comes from one of these sources and was checked against it.
- Dermal Fillers (Soft Tissue Fillers) · U.S. Food and Drug Administration
- FDA-Approved Dermal Fillers · U.S. Food and Drug Administration
- accessdata.fda.gov · U.S. Food and Drug Administration
- JUVÉDERM® Dermal Fillers | Restore Volume & Contour · juvederm.com
- How Juvéderm® Fillers Work · juvederm.com
- How Juvéderm® Fillers Work · juvederm.com
- restylaneusa.com · restylaneusa.com
- Dermal Fillers Cost · American Society of Plastic Surgeons
- HYLENEX RECOMBINANT- hyaluronidase injection, solution · DailyMed, U.S. National Library of Medicine
- Incidence and treatment of delayed-onset nodules after VYC filler injections to 2139 patients at a single Canadian clinic · Rivers, J Cosmet Dermatol, 2022
- What Is a Dissolving Lip Filler? · Cleveland Clinic
- JUVÉDERM® Day Returns to U.S. on August 19 · news.abbvie.com
- FAQs · mykybella.com
- Earn Restylane® Rewards & Savings · restylaneusa.com
Medical disclaimer. MedSpaStandard is for education only and is not medical advice. Talk to a licensed provider about your own health, and check any provider's license with your state board.