Part of the Botox guide · 10 articles

Where can you get Botox? Every treatment area on the face and body

Botox in the face is labeled for four areas: frown lines (the 11s), crow's feet, forehead lines — injected together with the frown lines — and platysma bands in the neck. Therapeutic Botox is separately approved for severe underarm sweating that topical agents have not adequately managed. Every other area marketed under the name — bunny lines, a lip flip, the masseter, chin, traps — is an off-label use, not on any current US label. Here is the area-by-area map.

4 areasLabeled Botox Cosmetic areasfrown lines, crow's feet, forehead lines, platysma bands
20 unitsFrown lineslabel dose: 4 units into each of 5 sites
24 unitsCrow's feetlabel dose: 12 units per side
26-36 unitsPlatysma (neck) bandslabel dose: 26, 31 or 36 units, by number of bands

Key takeaways

  • Botox Cosmetic's label covers four areas: frown lines, crow's feet, forehead lines and platysma (neck) bands.
  • Forehead lines are labeled only together with the frown lines: 40 units in total.
  • Therapeutic Botox is separately approved for severe underarm sweating, at 50 units per armpit.
  • Lip flip, gummy smile, masseter, chin, bunny lines and traps are off-label, and no label sets a dose for them.
  • Botox units cannot be compared to or converted into units of any other toxin brand.

Upper face: forehead lines, frown lines and crow's feet

Botox Cosmetic is approved in adults for the temporary improvement in the appearance of four areas: moderate to severe frown lines (glabellar lines, or the 11s), crow's feet (lateral canthal lines), forehead lines and platysma bands (vertical neck bands).

No other cosmetic area is on the label.

The frown-line indication came first of the four, with FDA approval on April 12, 2002. Crow's feet followed on September 11, 2013, and the forehead-lines indication on October 2, 2017.

The fourth labeled area, the platysma bands of the neck, came later still and is covered in the neck section below.

When each Botox Cosmetic area was approved

AreaFDA approval
Frown lines (glabellar lines)April 12, 2002
Crow's feet (lateral canthal lines)September 11, 2013
Forehead linesOctober 2, 2017
Platysma (neck) bandsOctober 18, 2024

Each labeled area carries a fixed dose in the label:

  • Frown lines. 20 units, given as 4 units into each of 5 sites — two in each corrugator muscle and one in the procerus.
  • Crow's feet. 24 units in total: 12 units per side, delivered as 4 units into each of 3 sites around the outer eye.
  • Forehead lines. No forehead-only dose. The label treats forehead lines together with the frown lines — 20 units to the forehead plus 20 units to the glabella, 40 units in total — to minimize the risk of a dropped brow.
  • All three upper-face areas in one session. 64 units; frown lines plus crow's feet, without the forehead, is 44 units.

Those are Botox Cosmetic numbers, and Botox Cosmetic units are product-specific: the label states they cannot be compared to or converted into units of any other botulinum toxin product. Dysport's only US cosmetic indication is frown lines, and only in adults younger than 65 — its label has no crow's-feet or forehead-lines indication. Xeomin covers all three upper-face areas; its label was expanded in July 2024 to cover the glabella, horizontal forehead lines and crow's feet together, at up to 64 units.

A chemical brow lift — Botox placed to raise the eyebrows rather than to soften lines — is a different goal, and Cleveland Clinic describes it as an off-label use, along with treatment of lip lines and neck laxity.

We could not find a label, consensus statement or high-quality study that gives a unit range for a brow lift; any dose a provider quotes for it is that injector's own.

Mid face: bunny lines, nose and under eyes

Below the eyes, the label stops.

No current US neurotoxin label lists the mid-face requests — bunny lines (the short diagonal lines that appear on the sides of the nose when you scrunch it), a nose injection meant to lift or refine the tip, or Botox under the eyes — for Botox or for any other brand.

Off-label here means the area is missing from the label, not that a different drug is used.

It is the same Botox Cosmetic, placed outside the four areas its label covers.

The boxed warning applies wherever Botox is placed

Botox Cosmetic carries an FDA boxed warning: toxin effects may spread from the injection area and cause symptoms such as generalized weakness, double vision, drooping eyelids, and swallowing or breathing difficulty, reported hours to weeks after injection. Swallowing and breathing problems can be life threatening and there have been reports of death. The label's statement that there have been no definitive serious adverse event reports of distant spread covers specific labeled doses — 20 units for frown lines, 24 units for crow's feet, 40 units for forehead plus frown lines, 44 or 64 units combined, and 100 units for underarm sweating — not off-label areas or higher doses.

Lower face: lips, chin, DAO (marionette lines), jowls and masseter

In the lower face, every area is off-label.

Cleveland Clinic's list of the off-label Botox uses it offers includes raising the corners of the mouth, softening lip creases, lip lengthening for a gummy smile, and chin softening for what it calls the “peach-pit chin”.

The DAO — the depressor anguli oris, the muscle that pulls the mouth corners down — is the muscle behind the marionette-lines request.

Lifting the mouth corners is off-label, and no US label lists the DAO.

Chin softening is off-label too.

So are jowls and the Nefertiti lift, a jawline-and-neck technique: not on any current US label, and we could not find published unit ranges for any of these areas, so the doses are the injector's own.

The lip flip everts (rolls out) the upper lip by relaxing the orbicularis oris, the muscle that rings the mouth.

It adds no volume — that is what lip filler does — and no US neurotoxin label includes the lips.

A 2025 systematic review reported that a lip flip typically uses 4 to 6 units into the orbicularis oris, with mild, transient after-effects such as temporary difficulty whistling or drinking through a straw.

Gummy smile work targets the muscles that lift the lip.

A 2024 systematic review of 13 controlled trials found the effect peaked at 2 to 4 weeks and lasted up to 12 to 24 weeks; the muscles most often targeted were the levator labii superioris alaeque nasi, the levator labii superioris and the zygomaticus minor.

A 2023 meta-analysis reported doses of 1.25 to 7.5 units per side and a reduction in gum show of up to 6 mm at 12 weeks.

Those are study figures for the people studied — not label doses, and not a prediction for any one person.

2–4 weeksGummy smile: peak effect2024 systematic review, 13 controlled trials
12–24 weeksGummy smile: effect lasted up to2024 systematic review, 13 controlled trials

The masseter — the muscle at the back angle of the jaw — rounds out the lower face.

Jaw slimming with masseter Botox is off-label in the US: the current Botox Cosmetic label, published in 2026, does not list masseter prominence, although AbbVie has run phase 2 and phase 3 trials of onabotulinumtoxinA for the jaw muscle.

AbbVie's phase 3 trial used 72 units in 376 adults, measured results at day 90 and found improvements holding through day 180.

51.2%72 units: at least a 2-grade masseter improvement at day 90AbbVie phase 3 trial, 376 adults
2.2%Placebo: at least a 2-grade improvement at day 90AbbVie phase 3 trial, 376 adults

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Neck and body: platysma bands, traps and underarms

The neck is where Botox's newest labeled area sits.

Platysma bands — the vertical bands that run from the jawline down the neck — were added to the Botox Cosmetic label on October 18, 2024, which makes Botox Cosmetic the only US neurotoxin currently labeled for neck bands.

The labeled dose is 26, 31 or 36 units, depending on how many bands are present (one or two per side), split between injections along the jawline and along each band.

Labeled Botox Cosmetic dose for platysma bands

Total units, by number of vertical bands

26 units
31 units
36 units
1 band per side1 band one side, 2 the other2 bands per side

Source: Botox Cosmetic label

The rest of the neck is off-label: the Nefertiti lift, jowl work and broader neck-loosening techniques are not on any current US label, and we could not find published unit ranges for them.

The on-label part of the neck is the vertical platysma bands specifically.

The trapezius — the muscle that caps the shoulder, marketed as “traptox” — is off-label as well: no US toxin label lists it.

Under the arms, the story changes.

Botox (the therapeutic product, not Botox Cosmetic) is approved for severe primary axillary hyperhidrosis — underarm sweating that topical agents have not adequately managed.

The labeled dose is 50 units per armpit, 100 units in total.

Botox and Botox Cosmetic contain the same active ingredient in the same formulation; what differs is the labeled indications.

For sweating in other body areas — the palms, the feet, the face — the label states that safety and effectiveness have not been established.

Botox Cosmetic

  • Frown lines, crow's feet, forehead lines and platysma bands
  • Same active ingredient and formulation as Botox

Botox (therapeutic)

  • Severe primary underarm sweating not adequately managed with topical agents
  • 50 units per armpit, 100 units in total
  • Palms, feet and face: safety and effectiveness not established

Botox units and cost per area

Four cosmetic areas carry a dose on the Botox Cosmetic label, therapeutic Botox sets a fifth — underarm sweating — and the off-label areas carry none, which is why unit counts, and prices, are easy to compare within the label and hard to compare outside it.

AreaLabel statusLabeled dose
Frown lines (the 11s)On label20 units (4 units into each of 5 sites)
Crow's feetOn label24 units (12 units per side)
Forehead linesOn label, treated with the frown lines20 units plus 20 units to the glabella — 40 units total; no forehead-only dose
All three upper-face areas in one sessionOn label64 units (44 units for frown lines plus crow's feet)
Platysma (neck) bandsOn label since October 202426, 31 or 36 units, depending on the number of bands
Underarm sweatingOn label — therapeutic Botox, not Botox Cosmetic50 units per armpit (100 units total)
Bunny lines, nose, under eyesOff labelNo labeled dose
Brow liftOff labelNo labeled dose
Lip flipOff labelNo labeled dose; a 2025 systematic review reports 4 to 6 units
Gummy smileOff labelNo labeled dose; a 2023 meta-analysis reported 1.25 to 7.5 units per side
Masseter (jaw slimming)Off labelNo labeled dose; AbbVie's phase 3 trial used 72 units
Chin, DAO, jowls, Nefertiti lift, trapeziusOff labelNo labeled dose

The labeled doses in the table come from the Botox Cosmetic and therapeutic Botox labels, and Botox units do not transfer between brands: the Botox Cosmetic label states its units cannot be compared to or converted into units of any other botulinum toxin product, and Dysport's label says the same.

The doses can look very different for the same area — Dysport's labeled frown-line dose is 50 units, given as five 10-unit injections, against Botox Cosmetic's 20 units.

20 unitsBotox Cosmetic: labeled frown-line doseBotox Cosmetic label
50 unitsDysport: labeled frown-line doseDysport label; units do not convert between brands

Practices typically price Botox per unit or per treatment area, and the label doses act as a floor for the unit count an area needs, so an area's price is roughly units times the practice's per-unit price.

We could not confirm a current national average price for neuromodulator injections — the ASPS statistics report for 2025 that we checked omits fees for minimally invasive procedures.

Ask each practice you are considering for its per-unit price and how many units it plans to use in each area, so quotes can be compared like for like.

Insurance follows the indication

The American Academy of Dermatology says insurance does not cover botulinum toxin for signs of aging, while treatment of excessive sweating may be at least partly covered, depending on the plan.

Frequently asked questions

Which areas is Botox FDA-approved for?

Four, for Botox Cosmetic in adults: moderate to severe frown lines (glabellar lines), crow's feet (lateral canthal lines), forehead lines and platysma bands (vertical neck bands).

The label treats forehead lines together with the frown lines, to minimize the risk of a dropped brow.

Therapeutic Botox has a separate approval for severe underarm sweating that topical agents have not adequately managed.

Everything else — bunny lines, lip flip, masseter, chin, jawline, trapezius — is off-label: it is not on any current US label for the product.

Is masseter Botox approved, or is it off-label?

Off-label in the US.

The current Botox Cosmetic label, published in 2026, does not list masseter prominence among its indications, although AbbVie has run phase 2 and phase 3 trials of onabotulinumtoxinA for the jaw muscle.

AbbVie's phase 3 trial used 72 units in 376 adults with marked or very marked masseter prominence.

It remains an off-label area today: no US label sets a dose for the masseter, so the dosing plan is the provider's own.

How many units of Botox does each area take?

For the on-label areas, the Botox Cosmetic label fixes the dose: 20 units for frown lines, 24 units for crow's feet (12 per side), 20 units to the forehead plus 20 units to the glabella when forehead lines are treated — 40 units in total — and 26, 31 or 36 units for platysma (neck) bands, depending on how many bands are present.

All three upper-face areas in one session total 64 units.

The off-label areas have no labeled dose.

Is Botox for underarms the same as cosmetic Botox?

It is the same drug with different labels.

Botox and Botox Cosmetic contain the same active ingredient in the same formulation, but the labeled indications differ: Botox Cosmetic covers the four cosmetic areas, while therapeutic Botox is approved for severe primary axillary hyperhidrosis — underarm sweating not adequately managed with topical agents — at a labeled dose of 50 units per armpit.

For sweating in other areas, such as the palms, feet or face, the label says safety and effectiveness have not been established.

Sources

Every number on this page comes from one of these sources and was checked against it.

  1. BOTOX COSMETIC- onabotulinumtoxina injection, powder, lyophilized, for solution · DailyMed, U.S. National Library of Medicine
  2. Drugs@FDA: FDA-Approved Drugs · U.S. Food and Drug Administration
  3. XEOMIN- incobotulinumtoxina injection, powder, lyophilized, for solution · DailyMed, U.S. National Library of Medicine
  4. DYSPORT- botulinum toxin type a injection, powder, lyophilized, for solution · DailyMed, U.S. National Library of Medicine
  5. BOTOX- onabotulinumtoxina injection, powder, lyophilized, for solution · DailyMed, U.S. National Library of Medicine
  6. The lip flip: a systematic review of botulinum toxin lip augmentation · Pitchford et al., Arch Dermatol Res, 2025
  7. Lip Flip Revisited: Clinical Outcomes and Neuromodulatory Basis of Upper Lip Eversion · Germani et al., Aesthetic Plast Surg, 2026
  8. Dose and injection site of botulinum toxin type A for gummy smile management: A systematic review and bibliometric analysis · Wang et al., Toxicon, 2024
  9. Non-Surgical Management of the Gingival Smile with Botulinum Toxin A-A Systematic Review and Meta-Analysis · Rojo-Sanchis et al., J Clin Med, 2023
  10. OnabotulinumtoxinA Treatment for Masseter Muscle Prominence: 6-Month Safety and Efficacy Results, Including Patient-Reported Outcomes, From a Phase 3, Randomized, Placebo-Controlled, Multiregional Trial · Sun et al., Aesthet Surg J, 2026
  11. Botulinum toxin therapy: Overview · American Academy of Dermatology
  12. Neuromodulators (Botox/Dysport/Xeomin): Plastic Surgery · Cleveland Clinic

Medical disclaimer. MedSpaStandard is for education only and is not medical advice. Talk to a licensed provider about your own health, and check any provider's license with your state board.