GLP-1 Results Statistics 2026

How well does GLP-1 work?

In real-world care (Gasoyan et al., Obesity 2025; 7,881 Cleveland Clinic adults without diabetes who started semaglutide or tirzepatide in 2021–2023), mean weight loss at one year was 8.7% — 11.9% for those who stayed on treatment, 6.8% for those who stopped after 3–12 months and 3.6% for those who stopped within 3 months — lower than in the phase 3 trials. [3]

SURMOUNT-1 (Jastreboff et al., NEJM 2022; n=2,539; 72 weeks, with lifestyle counseling): 85%, 89% and 91% of people on tirzepatide 5, 10 and 15 mg lost at least 5% of body weight vs 35% on placebo, and 50% (10 mg) and 57% (15 mg) lost 20% or more vs 3% on placebo. [1]

STEP 1 (Wilding et al., NEJM 2021; 68 weeks, with lifestyle intervention): 69.1% of people on semaglutide 2.4 mg lost at least 10% of body weight vs 12.0% on placebo; 4.5% on semaglutide stopped treatment because of gastrointestinal side effects vs 0.8% on placebo. [2]

How do patients rate GLP-1 providers on Google?

Google reviews of med spas offering GLP-1 average 4.87 stars, across 1,699,696 reviews of 13,139 rated listings.

96% of the Google reviews left for GLP-1 providers are 5-star.

86% of GLP-1 providers with at least 5 reviews hold a 4.8-star rating or better.

2.9% of the Google reviews left for GLP-1 providers give 1 or 2 stars.

0.8% of GLP-1 providers with at least 5 reviews average under 4.0 stars.

Google lists results as a review theme for 14% of GLP-1 providers with review themes.

Google lists natural-looking results as a review theme for 6.8% of GLP-1 providers with review themes.

What published research says

These numbers come from outside sources, not our directory; each one links to its source below.

• KFF (Oct–Nov 2025): among adults who had used a GLP-1 but stopped, 14% said they stopped because of cost and 13% because of side effects (both shares are of all ever-users). [4]
• Among 288 randomly sampled Cleveland Clinic patients who stopped semaglutide or tirzepatide for obesity within the first year (2022–2024), 47.6% stopped because of cost or insurance, 14.6% because of side effects, 11.8% because of shortages, 2.4% to switch to a compounded drug, and 1.7% for unsatisfactory weight loss (Gasoyan et al., Obesity 2025). [5]

What these numbers can't tell you

• Counts are Google Maps listings we classify as med spas, so they include dermatology and plastic surgery practices that offer med spa treatments and exclude spas without a Google listing.
• A treatment counts when the spa's Google listing or website names it, so a spa with an outdated menu can be over- or under-counted.
• Ratings and review themes are Google's, as shown on each listing on the snapshot date; Google filters some reviews and does not publish how.

Medical disclaimer. MedSpaStandard is for education only and is not medical advice. Talk to a licensed provider about your own health, and check any provider's license with your state board.